HUMAN PAPILLOMAVIRUS VACCINE DELIVERY STRATEGIES THAT ACHIEVED HIGH COVERAGE IN LOW- AND MIDDLE-INCOME COUNTRIES

Human papillomavirus vaccine delivery strategies that achieved high coverage in low- and middle-income countries

OBJECTIVE: To assess human papillomavirus (HPV) vaccination coverage after demonstration projects conducted in India, Peru, Uganda and Viet Nam by PATH and national governments and to explore the reasons for vaccine acceptance or refusal.METHODS: Vaccines were delivered through schools or health centres or in combination with other health intervent

read more

A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is among the cancer types with poorest prognosis and survival rates primarily due to resistance to standard-of-care therapies, including gemcitabine (GEM) and olaparib.Particularly, wild-type (wt)BRCA tumours, the most prevalent in PDAC, are more resistant to DNA-targeting agents like olap

read more